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From bronze to king, the road of advancement for scientific researchers (2) - Tutorial on the basic operation of cellular experiments

From bronze to king, the road of advancement for scientific researchers (2) - Tutorial on the basic operation of cellular experiments

Cell culture is the most basic operation for cell experiments. Through cell culture, we can obtain a large number of cells, which can be used for further research on cell function and signalling pathways, so the quality of cell culture will directly affect the subsequent cell experiments and the accuracy of the results.

09-11

An active targeting approach for the treatment of osteosarcoma with nanodelivery systems

Osteosarcoma is the most common in situ tumour of bone, accounting for approximately 35% of bone malignancies. The main symptoms of patients with osteosarcoma include restricted mobility, swelling, severe pain, and pathological fracture, and approximately 10-20% of patients have metastases at the time of their initial consultation. Conventional treatment includes early surgical resection and adjuvant chemotherapy, but a larger proportion of patients still respond poorly to treatment. The current first-line chemotherapeutic agents include adriamycin, cisplatin and methotrexate, which synergistically exert anti-tumour effects through different mechanisms of action, but due to the lack of selectivity of these agents and more pronounced systemic toxicity when applied in high doses, new therapeutic approaches need to be explored.

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Principles of Transdermal Cell Therapy - TCR-T

Recently, Cell Reports Medicine, an internationally renowned journal, released the Phase I clinical research results of TAEST16001, the first TCR-T therapy product in China [1].TAEST16001 is used for the treatment of advanced soft-tissue sarcoma, which is a key step towards the clinical translation of ACT in the field of solid tumours, and once again ignited people's confidence in the treatment of solid tumours with TCR-T therapies. confidence in TCR-T therapy for solid tumours. In this issue, let's talk about the ins and outs of TCR-T therapy.

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