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2022-04
NK cells can be used in consolidation therapy for multiple myeloma
To date, multiple myeloma remains an incurable disease and autologous haematopoietic stem cell transplantation is one of the mainstays of treatment, often followed by long-term maintenance therapy with immunomodulators or proteasome inhibitors. However, due to the average age of patients receiving a diagnosis of 65-70 years, the use of autologous HSCT therapy to achieve long-term control of disease progression is not realistic. In addition, there are many serious side effects associated with the long-term use of maintenance therapy, including the risk of haematopenia, thrombosis, secondary malignancy and neuropathy. A promising approach is the use of alternative cell therapy as consolidation after autologous HSCT, which does not have the side effects of maintenance therapy.
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2022-04
As we all know, when we have a blood transfusion, the doctor needs to know your blood type and choose the same blood type in order not to cause serious blood clotting, a life-threatening symptom; however, there is also a special blood type - blood type O. Since there are no A antigens and B antigens on the red blood cells of blood type O, it does not cause an immune response, which is also known as universal blood.
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2022-04
Treatment of a common disease of ageing: "New weapon" for dry eye - NAD+
NAD+, a key metabolite of the cellular universal currency, has attracted a lot of attention in the scientific community over the past few years for its ability to prevent or delay the progression of aging-related diseases. Studies from many laboratories around the world have identified the role of NAD+-regulated pathways in the prevention of cellular senescence, such as energy metabolism, DNA damage repair, epigenetic modifications, gene expression and stress responses.
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2022-03
Vigilance! Senescent Immune Cells Age Bones
The human skeleton undergoes a continuous remodelling process throughout adulthood to repair small cracks that keep appearing. This remodelling process is precisely balanced between osteoblastic bone formation and osteoclastic bone resorption. However, with age, this homeostasis is markedly compromised in terms of reduced bone remodelling and accumulation of bone marrow fat, which in turn can lead to bone fragility, particularly as bone marrow mesenchymal stem cells (BMSCs), the sole cellular source of osteoblasts, are prone to fat formation rather than bone formation during ageing. Current research suggests that this is caused by mediators in the bone marrow microenvironment, whose primary function is to support and regulate the skeletal function of various cell types, including haematopoietic and mesenchymal cells, in order to maintain homeostasis in the body.
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2022-03
SUMOylation is a reversible post-translational modification associated with cancer. Many post-translational modifications occur on proteins, mainly controlling protein function, localisation and stability, and regulation of proteins by reversible post-translational modifications, such as phosphorylation and ubiquitination, enhances cellular response to stress. Numerous proteomics studies have revealed differences in post-translational modifications between healthy and tumour tissues: phosphorylation and ubiquitination are abnormally elevated in a wide range of cancers, and many protein kinase inhibitors as well as inhibitors of the ubiquitination pathway have been clinically used for the treatment of different types of tumours; however, their specificity is still a major obstacle to cancer therapy.
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2022-02
The Winter Olympics closed successfully, and during this Winter Olympics there was an extremely widely participated discussion: should you get enough 10 hours of sleep every night? It sparked a hot debate about sleep on social networks. How do you understand this whole sleep thing from a medical and genetic point of view?
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