HUAREN MEDICAL TECHNOLOGY
STEM CELLS
Jun 06,2023
Iron death and the feud over mesenchymal stem cell therapy
Iron death? What was your first thought? Did you think that iron also dies? If you think so, you are wrong, Iron death is a new type of regulated cell death, this unique mode of cell death is driven by iron-dependent phospholipid peroxidation, regulated by a variety of cellular metabolic events, and is involved in a number of signaling pathways related to disease development. Since the emergence of the term "iron death" in 2012, the research on iron death has increased exponentially in recent years, and has been recognized as a research hotspot of the National Natural Science Foundation of China for consecutive years. Today, I would like to talk about what iron death is, what diseases iron death plays an important role, and whether mesenchymal stem cells, which have made a big splash in the field of therapeutics, also have a significant role in disease damage induced by iron death. The mesenchymal stem cells have an unexpected effect on iron death-induced disease damage.
May 31,2023
Human umbilical cord mesenchymal stem cells and clinical therapy
Human umbilical cord mesenchymal stem cells (HUC-MSCs) are a kind of pluripotent stem cells existing in the umbilical cord tissue of newborn babies, which have strong proliferation and self-renewal ability and can be differentiated into one or more kinds of human tissues or organs under certain conditions. Through autologous/allogeneic transplantation, the structure and function of tissues and organs can be reconstructed, and immune rejection can be avoided. It is because of these immunological properties of HUC-MSCs that they have broad clinical application prospects in autoimmune diseases and various alternative therapies. In recent years, HUC-MSCs have been widely used by the medical community in the treatment of various diseases, resulting in many successful cases.
Apr 18,2023
Stem cells in chronic wound healing
Trauma, burns, and many chronic diseases, such as diabetes and peripheral vascular disease, can lead to chronic refractory wounds. As the prevalence of obesity and diabetes rises, so does the incidence of chronic wounds. Such wounds pose a great challenge for clinical management and have a serious impact on the patient's image and psychology. Currently, treatments for chronic wounds include debridement, topical antibiotics, compression bandages, skin grafts, and growth factors. However, the therapeutic effects are not satisfactory, so there is an urgent need to explore new approaches.
Apr 16,2023
A new mechanism of action for mesenchymal stem cells - mitochondrial therapy
MSCs are one of the most commonly used candidate cells in regenerative medicine research and show great potential in clinical therapy, improving tissue function and treating various diseases through mechanisms of action such as secretion of factors, transfer of extracellular vesicles, migration to the site of injury, differentiation into different cells, and restoration of cell function [1]. The cellular state of pathological environments in clinical settings can be affected, causing damage to cellular mitochondria, leading to a decrease in ATP production and triggering impaired cellular function or even death. Recently, a new strategy called mitochondrial therapy is being investigated for different diseases, based on the principle of using exogenous mitochondria to transfer into cells and thus repair the pathological state. MSCs, a pioneer in the field of cellular therapy, can serve as a good donor for the transfer of functional mitochondria into damaged cells (Figure 1) [2]. Studies have shown that mitochondrial transfer of MSCs can affect other cells in important processes such as proliferation, differentiation, metabolism, inflammatory response, senescence, stress and migration [3].
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