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2023-04
How to efficiently complete the preparation of animal models of knee osteoarthritis
Osteoarthritis (OA) is a chronic degenerative joint disease that mainly occurs in the middle-aged and elderly population, with degeneration of articular cartilage and osteophytes as the pathological features, and clinical manifestations such as joint pain, swelling, stiffness, and limited activities, which can lead to joint dysfunction and disability, and the prevalence of osteoarthritis of the knee in our country ranges from 5 to 30% [1]. The risk factors for osteoarthritis are mechanical and non-mechanical, mechanical factors include anterior cruciate ligament rupture, meniscus tear, muscle misalignment, etc., while non-mechanical factors include genetics, obesity, age, gender and inflammation. These risk factors may contribute to the development of osteoarthritis with different characteristics. Animal experimentation is an important vehicle for drug development and plays an important role in the drug development process.
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2023-04
How nanotechnology can help CAR-T cell immunotherapy
How nanotechnology can help CAR-T cell immunotherapy CAR, or chimeric antigen receptor, has a modular design consisting of an extracellular antigen-binding structural domain, a hinge, a transmembrane structural domain, and an intracellular signalling structural domain. The antigen-binding domain is derived from the single-chain antibody scFv and contains the variable heavy chain (VH) and variable light chain (VL), a region responsible for antigen recognition. The intracellular signalling domain contains CD3ζ derived from the T-cell receptor (TCR), and when the scFv of the antigen-binding domain binds to an antigen, TCR-like signals are transmitted intracellularly and activate the T-cell. The transmembrane structural domain, on the other hand, acts as a link between the intracellular and extracellular compartments, anchoring the CAR structure to the T cell membrane.
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2023-03
Methods of constructing animal models of hyperlipidaemia
In medical research, the establishment of animal models is often a problem that many researchers need to consider, and the quality of the construction of animal models is related to the success of our research projects. Hyperlipidaemia is the most common type of metabolic disease, and most of them are caused by long-term irregular diets high in fat and calories.
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2023-03
Can mesenchymal stem cells be used in the treatment of human azoospermia?
According to the World Health Organisation, as many as one in six married couples in the world cannot conceive naturally. Of these, 20-30 per cent of infertility is related to men. Azoospermia is a condition that causes male infertility, of which non-obstructive azoospermia (NOA) is the most serious, mainly due to the dysfunction of spermatogenesis in the testes, which fails to produce functional spermatozoa.NOA accounts for 60% of the men with azoospermia, and more than 70% of patients with non-obstructive azoospermia are unable to obtain spermatozoa even with surgical manipulation.Currently there are no effective treatments available for patients with non-obstructive azoospermia. There is no effective treatment for patients with non-obstructive azoospermia.
View More14
2023-03
Laboratory animals and their welfare protection
Laboratory animals are animals that have been artificially bred or artificially modified to control the microorganisms they carry; have a clear genetic background and a clear origin, and are used for scientific experiments, the production and testing of medicines and biological products, and other scientific experiments. Simply put, they are animals specially bred for experiments.
View More05
2023-03
In recent years, nanotechnology has been widely used in the field of biomedicine. Electrostatic spinning technology as one of the nanotechnologies has the advantages of simple operation, low cost, higher yield and controllable process. Electrospinning is a spinning technology that uses polymer fluids to obtain nanoscale fibres by stretching them under the action of a strong electric field and jetting them through a metal nozzle.
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